Mutual regulation between glycosylation and transforming growth factor-β isoforms signaling pathway

Z Chen, H Yu, X Chen, W Chen, W Song, Z Li - International Journal of …, 2023 - Elsevier
… evidences associate glycosylation modification with TGF-β signaling pathway, and we can
… the activation of TGF-β/Smad2/3 signaling and attenuated UUO-induced renal fibrosis [92]. …

Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

YY Chen, XY Yu, L Chen, ND Vaziri, SC Ma… - Free Radical Biology and …, 2019 - Elsevier
… against unilateral ureteral obstruction-induced renal fibrosis, … TGF-β-induced ROS generation
through a TGF-β/Smad/ROS … Nrf2 activity could effectively attenuate fibrogenesis in animal …

[HTML][HTML] Plant flavonoids on oxidative stress-mediated kidney inflammation

S Alsawaf, F Alnuaimi, S Afzal, RM Thomas… - Biology, 2022 - mdpi.com
… Flavonoids exert protective effects by decreasing the excessive ROS level or activating …
attenuates hyperuricemia-induced kidney injury by modulating STAT3 and TGF-β signaling

The anti-fibrotic and anti-inflammatory effects of 2, 4-diamino-5-(1-hydroxynaphthalen-2-yl)-5H-chromeno [2, 3-b] pyriine-3-carbonitrile in corneal fibroblasts

YJ Chen, SM Huang, MC Tai, JT Chen, AR Lee… - Pharmacological …, 2020 - Springer
… with N1 significantly attenuated phosphorylation of both STAT3 … N1 exerts anti-fibrotic and
anti-inflammatory effects through … roles in relaying extracellular TGF-β signals, and that Smad3 …

[HTML][HTML] Glucosamine impedes transforming growth factor β1-mediated corneal fibroblast differentiation by targeting Krüppel-like factor 4

YJ Chen, SM Huang, MC Tai… - Journal of …, 2019 - jbiomedsci.biomedcentral.com
… whether GlcN affects signaling via TGF-β receptors (TGF-βRs… in human renal epithelial cells
to attenuate TGF-β signaling [… epithelial cells exerts diverse effects during renal fibrosis and …

[HTML][HTML] Glucosamine inhibits extracellular matrix accumulation in experimental diabetic nephropathy

L Teuma, R Eshwaran, U Tawokam Fongang… - Frontiers in …, 2022 - frontiersin.org
glucosamine in a model of non-diabetic renal fibrosis. A down-regulation of the TGF-β signaling
… Dapagliflozin attenuates renal tubulointerstitial fibrosis associated with type 1 diabetes …

[HTML][HTML] Abelmoschus esculentus subfractions improved nephropathy with regulating dipeptidyl peptidase-4 and type 1 glucagon-like peptide receptor in type 2 …

CH Peng, HC Lin, CL Lin, CJ Wang… - Journal of food and drug …, 2019 - Elsevier
… F2 was most effective in attenuating hyperglycemia and insulin … F2 and FR exerted significant
effects to decrease DPP-4 but … by inhibiting N-linked glycosylation of the TGF-β receptor, …

Autologous-Versus Allogeneic-Bone Marrow Cell Grafting in Prevention of Obstructive Nephropathy in Rats

A Fattah, MH AL Badawi… - Egyptian Journal of …, 2019 - journals.ekb.eg
… a protective effect and ameliorated interstitial fibrosis as reflected … TGF-β was a key player in
renal epithelial to mesenchymal … against unilateral ureteral obstruction-induced renal fibrosis

[HTML][HTML] Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome

HW Chiu, LH Li, CY Hsieh, YK Rao, FH Chen… - Scientific reports, 2019 - nature.com
… been developed and shown to attenuate NLRP3-associated … In addition to its joint-protective
effects, glucosamine exerts … hypothesize that the protective effects of glucosamine may be …

[HTML][HTML] hUMSCs regulate the differentiation of ovarian stromal cells via TGF-β1/Smad3 signaling pathway to inhibit ovarian fibrosis to repair ovarian function in POI …

L Cui, H Bao, Z Liu, X Man, H Liu… - … Cell Research & …, 2020 - stemcellres.biomedcentral.com
… that the TGF-β 1 /Smad3 signaling pathway was involved in the inhibition of ovarian tissue
fibrosis, … pathway has been involved in the pathogenesis of renal fibrosis [21, 22]. During the …